evaluation of a trivalent pasteurella multocida vaccine consisted of serotypes 1, 3 and 4.
نویسندگان
چکیده
an inactivated trivalent fowl cholera vaccine consisted of serotypes 1, 3 and 4 pasteurella multocida strains was prepared. the vaccine provided 70-100% protection against challenge with homologous starins. elisa assay showed a considerable increase in antibody titer after towice vaccination of 8 weeks chickens. it was found that the trivalent vaccine can induce immunogenic response in vaccinated chickens.
منابع مشابه
Evaluation of a Trivalent Pasteurella multocida Vaccine Consisted of Serotypes 1, 3 and 4.
An inactivated trivalent fowl cholera vaccine consisted of serotypes 1, 3 and 4 Pasteurella multocida strains was prepared. The vaccine provided 70-100% protection against challenge with homologous starins. ELISA assay showed a considerable increase in antibody titer after towice vaccination of 8 weeks chickens. It was found that the trivalent vaccine can induce immunogenic response in vaccinat...
متن کاملCharacterization of neuraminidases produced by various serotypes of Pasteurella multocida.
Neuraminidases produced by 16 strains of Pasteurella multocida (serotypes 1 to 16) were characterized by molecular weight, substrate specificity, and antigenic identity. After growth in a chemically defined medium, stage I (lyophilized) culture supernatants were assayed for activity with N-acetylneuramin lactose, human alpha-1-acid glycoprotein, fetuin, colominic acid, and bovine submaxillary m...
متن کاملEvaluation of immunogenicity and protective efficacy of recombinant ptfA of avian Pasteurella multocida
Avian Pasteurella multocida is the causative agent of fowl cholera, a disease much affecting the poultry industry. In order to study the efficacy of the recombinant subunit vaccine constructed with ptfA gene of avian P. multocida, the ptfA gene fragment amplified by PCR from avian P. multocida was cloned into the prokaryotic expression vector pET32a and the recombinant plasmid pET32a-ptfA was o...
متن کاملFormulation of an effective Pasteurella multocida vaccine for sheep.
An effective vaccine for the immunization of sheep against Pasteurella multocida infection was prepared from P. multocida Strain D4 (Type D) and a selected strain of P. multocida Type A. Provided an adequate concentration of bacteria was used, the vaccine thus formulated induced antibodies in sheep that protected mice not only against the vaccine strains but also against infection by a number o...
متن کاملPathogenomics of Pasteurella multocida.
The first complete genome sequence of the P. multocida avian isolate Pm70 was reported in 2001. Analysis of the genome identified many predicted virulence genes, including two encoding homologues of the Bordetella pertussis filamentous haemagluttinins, and genes involved in iron transport and metabolism. Availability of the genome sequence allowed for a range of whole-genome trans...
متن کاملA potassium thiocyanate extract vaccine prepared from Pasteurella multocida 3:A protects rabbits against homologous challenge.
Potassium thiocyanate extracts of a virulent Pasteurella multocida 3:A rabbit isolate were prepared and used as a vaccine in rabbits. The extract contained protein, carbohydrate, hyaluronic acid, lipopolysaccharide, DNA, and RNA. The protein and lipopolysaccharide profiles of the extract were similar to those of the P. multocida cell membrane. Rabbits were vaccinated intranasally (i.n.) or intr...
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عنوان ژورنال:
archives of razi instituteناشر: razi vaccine & serum research institute (rvsri)
ISSN 0365-3439
دوره 59
شماره 1 2016
کلمات کلیدی
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